![]() The messenger RNA precursors that encode inflammatory cytokines and related proteins are identified in the inner ear by using reverse transcriptase–polymerase chain reaction. Such disruptions may explain previously poorly understood cochlear pathologies. The presence of these receptors makes the cells vulnerable to disruption by circulating or local sources of cytokines and related ligands. Cytokines are autocrine, which means that cells that produce them have corresponding surface receptors. Inflammatory cytokines and related proteins play critical roles in a variety of cellular processes, but to date, little is known about the identity and cellular localization of these compounds within the ear. Establishing the presence of critical cellular stress response components in cochlear cells can contribute to a better understanding of cochlear cell biology and pathology.
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